Protein Kinase C-theta

A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.

Also Known As:

PKC-theta; PRKCQ; Protein Kinase C theta; Protein Kinase C, theta; PKC theta

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Protein Kinase C: 5856
        Protein Kinase C-theta: 123
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Protein Kinase C: 5856
        Protein Kinase C-theta: 123

Shinya Nagashima Selected Research

Shinya Nagashima Research Topics

Disease

Drug/Important Bio-Agent (IBA)